Placentally-derived products have been used successfully in medicine as wound healing adjuncts for many years. Since its introduction in 2010, BioXclude has found many uses in oral and maxillofacial surgery and oral implantology, and continues to gain popularity among clinicians due to its rather unique benefits in wound healing and handling that other types of barrier membranes do not possess. This lecture will review the basic science of amnion-chorion membranes and why they are so beneficial to wound healing and bone grafting procedures. Various clinical cases will be presented that highlight different clinical applications of the membrane. Emphasis will be placed on demonstrating standard and novel ways of using the membrane as well as avoiding potential pitfalls.